{"id":13750,"date":"2022-01-21T16:10:28","date_gmt":"2022-01-21T16:10:28","guid":{"rendered":"https:\/\/aqtn.ca\/questions\/?p=13750"},"modified":"2025-09-11T08:13:02","modified_gmt":"2025-09-11T08:13:02","slug":"rapports-macronutriments","status":"publish","type":"post","link":"https:\/\/aqtn.ca\/questions\/association-quebec-aqtn-other-posts\/rapports-macronutriments\/","title":{"rendered":"Precision Medicine – Le futur de la m\u00e9decine personnalis\u00e9e (Article par DNA Labs)"},"content":{"rendered":"

Article partag\u00e9e avec permission par DNA Labs<\/a><\/p>\n

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Test g\u00e9n\u00e9tique de Lifestyle LoveMyHealth\u2122 (65 g\u00e8nes avec 8 cat\u00e9gories)<\/a><\/h3>\n

DNA Labs travaille \u00e0 offrir des tests g\u00e9n\u00e9tiques afin d’outiller les th\u00e9rapeutes ainsi que le public avec des informations personnalis\u00e9es permettant de faire des d\u00e9cisions menant \u00e0 une meilleure prise en charge de sa sant\u00e9 avec des marqueurs connus.
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99 Yorkville Avenue, Suite 200
\nToronto, Ontario, M5R 3K5
\nCanada<\/td>\n		3651 FAU Boulevard, Suite 400
\nBoca Raton, Florida, 33431
\nU.S.A.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div>\n<\/div>\n
Rapports de macronutriments<\/div><\/div>\n
Graisses totales (Lipides)<\/div>
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Les variations des g\u00e8nes TCF7L2<\/strong> et LIPC<\/strong> modifient les taux d’insuline et de cholest\u00e9rol en r\u00e9ponse aux graisses alimentaires et contribuent \u00e0 orienter les recommandations en mati\u00e8re de consommation de graisses totales.<\/p>\n

Des \u00e9tudes montrent que les personnes pr\u00e9sentant le g\u00e9notype TT du g\u00e8ne TCF7L2<\/strong> (rs12255372) pr\u00e9sentent une diminution plus importante de l’IMC, de la masse grasse totale et de la masse grasse du tronc (tous les P<0,05) apr\u00e8s 6 mois de r\u00e9gime pauvre en graisses (< 20%) par rapport aux g\u00e9notypes CT et CC. En outre, les personnes porteuses du TT pr\u00e9sentent un meilleur contr\u00f4le glyc\u00e9mique avec des r\u00e9ductions du glucose et de l’insuline plasmatiques lors d’un r\u00e9gime pauvre en graisses.<\/p>\n

Le LIPC<\/strong> est un g\u00e8ne qui produit une enzyme h\u00e9patique (lipase h\u00e9patique), laquelle r\u00e9gule le m\u00e9tabolisme des lipoprot\u00e9ines et la distribution du cholest\u00e9rol dans l’organisme. Les personnes pr\u00e9sentant l’all\u00e8le T du SNP rs1800588 ont des concentrations de cholest\u00e9rol HDL (HDL-C) plus \u00e9lev\u00e9es lorsqu’elles consomment moins de 30 % de l’\u00e9nergie provenant des graisses (P<0,001). En revanche, lorsque la consommation de graisses totales repr\u00e9sente plus de 30 % de l’apport calorique total, les concentrations de HDL-C sont plus faibles chez les personnes pr\u00e9sentant le g\u00e9notype TT, par rapport aux individus CC et CT.
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Glucides<\/div>
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Les variantes des g\u00e8nes TCF7L2 (rs12255372) et CRY1 (rs2287161) influencent la s\u00e9cr\u00e9tion d’insuline, le HOMA-IR (marqueur de r\u00e9sistance \u00e0 l’insuline) et le risque de diab\u00e8te de type 2. De nombreuses \u00e9tudes montrent que les modifications du r\u00e9gime alimentaire en termes de qualit\u00e9 et de quantit\u00e9 de glucides modifient les effets de ces g\u00e8nes.<\/p>\n

Les personnes pr\u00e9sentant le g\u00e9notype TCF7L2 TT ont un risque jusqu’\u00e0 2 fois plus \u00e9lev\u00e9 de d\u00e9velopper un DT2 ; cependant, l’ampleur de l’association est \u00e9limin\u00e9e chez ceux qui consomment un r\u00e9gime riche en fibres et \u00e0 faible indice glyc\u00e9mique ; tandis que les g\u00e9notypes CRY1 CC qui consomment un r\u00e9gime pauvre en glucides (< 41,65 %) pr\u00e9sentent une am\u00e9lioration de la sensibilit\u00e9 \u00e0 l’insuline.
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Prot\u00e9ines<\/div>
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Il est int\u00e9ressant de noter que le g\u00e8ne de la masse grasse et de l’ob\u00e9sit\u00e9 (FTO<\/strong>) a un impact significatif sur la r\u00e9ponse \u00e0 la consommation de prot\u00e9ines et \u00e0 la perte de poids.<\/p>\n

Les personnes porteuses de l’all\u00e8le \u00e0 risque A* qui suivent un r\u00e9gime hypocalorique (750 kcal\/j) et riche en prot\u00e9ines pr\u00e9sentent moins d’envies de manger et une r\u00e9duction de l’app\u00e9tit par rapport aux personnes porteuses du g\u00e9notype sauvage TT-.<\/p>\n

Merci \u00e0 notre partenaire :\u00a0 https:\/\/dnalabs.ca\/precision-medicine\/<\/a>
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\n<\/div><\/div>\n<\/div>\n<\/div><\/div><\/h3>\n","protected":false},"excerpt":{"rendered":"

Article partag\u00e9e avec permission par DNA Labs<\/p>\n","protected":false},"author":27,"featured_media":8892,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[1,1576],"tags":[2519,2450,2446,2449,2607,2614,2613],"class_list":["post-13750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-association-quebec-aqtn-other-posts","category-naturopathie","tag-cholesterol","tag-dna","tag-dna-labs","tag-genetics","tag-precision-medicine","tag-proteines","tag-proteins"],"yoast_head":"\nPrecision Medicine – Le futur de la m\u00e9decine personnalis\u00e9e (Article par DNA Labs) - 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