{"id":33831,"date":"2026-11-04T16:30:36","date_gmt":"2026-11-04T16:30:36","guid":{"rendered":"https:\/\/aqtn.ca\/questions\/?p=33831"},"modified":"2026-11-03T20:38:03","modified_gmt":"2026-11-03T20:38:03","slug":"prise-de-sang-sante-cerveau-demence","status":"publish","type":"post","link":"https:\/\/aqtn.ca\/questions\/association-quebec-aqtn-other-posts\/prise-de-sang-sante-cerveau-demence\/","title":{"rendered":"Prise de sang et sant\u00e9 du cerveau : une piste pour mieux comprendre le risque de d\u00e9mence"},"content":{"rendered":"
\n

Recherche \u00b7 Sant\u00e9 du cerveau<\/p>\n

Et si certains r\u00e9sultats sanguins pouvaient fournir des indices sur la sant\u00e9 future du cerveau? Une vaste \u00e9tude explore le lien entre un marqueur d\u2019inflammation et le risque de d\u00e9velopper la maladie d\u2019Alzheimer ou d\u2019autres d\u00e9mences.<\/p>\n

\n

L\u2019essentiel en quelques mots<\/strong><\/p>\n

Un rapport neutrophiles\/lymphocytes plus \u00e9lev\u00e9 a \u00e9t\u00e9 associ\u00e9 \u00e0 un risque accru de d\u00e9mence dans deux grandes populations. Cette observation constitue une piste de recherche : elle ne permet pas, \u00e0 elle seule, de poser un diagnostic ou de pr\u00e9dire l\u2019avenir d\u2019une personne.<\/p>\n<\/div>\n

Ce que les chercheurs ont observ\u00e9<\/h2>\n

Publi\u00e9e en avril 2026 dans la revue Alzheimer\u2019s & Dementia<\/em>, l\u2019\u00e9tude s\u2019appuie sur les dossiers m\u00e9dicaux de pr\u00e8s de 370 000 adultes de plus de 55 ans<\/strong>, issus de deux r\u00e9seaux de soins am\u00e9ricains : NYU Langone et la Veterans Health Administration. Aucun participant n\u2019avait de diagnostic de d\u00e9mence au d\u00e9part.<\/p>\n

Dans les deux groupes, les chercheurs ont constat\u00e9 une association entre un rapport neutrophiles\/lymphocytes plus \u00e9lev\u00e9 et un diagnostic ult\u00e9rieur de maladie d\u2019Alzheimer ou d\u2019autres d\u00e9mences. Cette association persistait apr\u00e8s ajustement pour plusieurs facteurs d\u00e9mographiques et cliniques.<\/p>\n

Qu\u2019est-ce que le rapport neutrophiles\/lymphocytes?<\/h2>\n

Les neutrophiles<\/strong> et les lymphocytes<\/strong> sont deux cat\u00e9gories de globules blancs qui participent aux d\u00e9fenses immunitaires. Leur rapport, souvent d\u00e9sign\u00e9 par l\u2019abr\u00e9viation anglaise NLR<\/strong>, peut \u00eatre calcul\u00e9 lorsque leurs num\u00e9rations sont disponibles dans une formule sanguine avec diff\u00e9rentiel.<\/p>\n

Ce rapport fournit un indicateur indirect de l\u2019inflammation dans l\u2019organisme. Les chercheurs s\u2019y int\u00e9ressent pour mieux comprendre les liens entre le syst\u00e8me immunitaire et le vieillissement c\u00e9r\u00e9bral.<\/p>\n

Une association ne prouve pas une cause<\/h2>\n

L\u2019\u00e9tude est observationnelle. Elle ne d\u00e9montre donc pas qu\u2019un rapport \u00e9lev\u00e9 provoque une d\u00e9mence, ni que le faire diminuer permettrait de pr\u00e9venir la maladie. Les chercheurs doivent encore d\u00e9terminer si les neutrophiles contribuent directement \u00e0 la progression de la maladie ou s\u2019ils constituent surtout un marqueur de processus sous-jacents.<\/p>\n

\n

Comment interpr\u00e9ter cette nouvelle?<\/strong><\/p>\n

Une prise de sang courante ne devient pas pour autant un test de d\u00e9pistage d\u2019Alzheimer. Un r\u00e9sultat individuel doit \u00eatre interpr\u00e9t\u00e9 par un professionnel m\u00e9dical en tenant compte de l\u2019ensemble du contexte clinique.<\/p>\n<\/div>\n

Une piste \u00e0 suivre<\/h2>\n

Cette recherche renforce l\u2019int\u00e9r\u00eat scientifique pour les interactions entre l\u2019inflammation et la sant\u00e9 du cerveau. D\u2019autres \u00e9tudes devront pr\u00e9ciser l\u2019utilit\u00e9 du NLR dans l\u2019\u00e9valuation du risque et v\u00e9rifier si les m\u00e9canismes en jeu peuvent devenir des cibles de pr\u00e9vention ou de traitement.<\/p>\n

\n

Sources et lecture compl\u00e9mentaire<\/h2>\n

Ce billet propose un r\u00e9sum\u00e9 en fran\u00e7ais du sujet pr\u00e9sent\u00e9 sur Yahoo Sant\u00e9, compl\u00e9t\u00e9 par la consultation de l\u2019\u00e9tude originale.<\/p>\n

Lire l\u2019article sur Yahoo Sant\u00e9<\/a>
Article de vulgarisation en anglais.<\/small><\/p>\n

\n

L\u2019\u00e9tude originale<\/h3>\n

Aper\u00e7u de la premi\u00e8re page publi\u00e9e dans Alzheimer\u2019s & Dementia<\/em>.<\/p>\n

\"Premi\u00e8re<\/a><\/p>\n

Premi\u00e8re page en anglais \u00b7 Cliquez sur l\u2019image pour l\u2019agrandir.<\/p>\n

Consulter l\u2019\u00e9tude scientifique<\/a><\/p>\n

Notice et liens vers le texte int\u00e9gral sur PubMed \u00b7 En anglais.<\/p>\n<\/div>\n

R\u00e9f\u00e9rence :<\/strong> He et coll. (2026). Neutrophil inflammation metrics are associated with the risk of future dementia in large data from NYU Langone Hospitals and the Veterans Health Administration.<\/em> Alzheimer\u2019s & Dementia, 22, e71335. DOI : 10.1002\/alz.71335<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Recherche \u00b7 Sant\u00e9 du cerveau Et si certains r\u00e9sultats sanguins pouvaient fournir des indices sur la sant\u00e9 future du cerveau? Une vaste \u00e9tude explore le lien entre un marqueur d\u2019inflammation et le risque de d\u00e9velopper la maladie d\u2019Alzheimer ou d\u2019autres d\u00e9mences. L\u2019essentiel en quelques mots Un rapport neutrophiles\/lymphocytes plus \u00e9lev\u00e9 a \u00e9t\u00e9 associ\u00e9 \u00e0 un […]<\/p>\n","protected":false},"author":27,"featured_media":33837,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"nfd_image_url":"","nfd_onboarding_generated":"","footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[1585,1,2605,2490,2591],"tags":[],"class_list":["post-33831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bienfaits-pour-la-sante","category-association-quebec-aqtn-other-posts","category-education","category-formations-continue","category-francais"],"yoast_head":"\nPrise de sang et sant\u00e9 du cerveau : \u00e9tude sur la d\u00e9mence | AQTN<\/title>\n<meta name=\"description\" content=\"Une \u00e9tude explore le lien entre inflammation sanguine et risque de d\u00e9mence. 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